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Influence of nanomaterials (based on bentonitic clays and calcium carbonate) in pelagic sediments of the Black Sea on their biologic activity has been investigated. It was shown that chemical composition, pre-liminary thermal treatment and concentration of nanomaterials in composition with pelagic sediments have a great influence to their medical properties. Based on obtained data for complex influence of nano-composites to organism (behaviour, nervimuscular irritability, reflexes, vegetative effects, functional condi-tion of lever and kidneys) a conclusion of substantially increasing the biological activity of pelagic sedi-ments with the properties of medicinal mud (peloid), under the influence of bentonite and calcium carbon-ate that contain nanoparticles. A method for testing the pelagic sea and ocean sediments with nanodis-persed components to predict the prospects of their use as medicinal muds (peloids) has been suggested.